Pharmacological Effects Triamcinolone Acetonide:
Triamcinolone Acetonide GCS, inhibits the release of interleykina1, interleykina2, interferon gamma from lymphocytes and macrophages. Induces the formation lipokortina inhibits the release of eosinophil mediators of inflammation and stabilizes the membranes of fat cells. Has anti-inflammatory, antiallergic, anti-action. Reduces bronchial hyperreactivity, restores the sensitivity of receptors to beta-agonist, stabilizes mast cell membranes, reduces the number of mast cells, macrophages, T-lymphocytes and eosinophils in the epithelium and submucosal layer of bronchi. At therapeutic doses, has almost no systemic action, does not inhibit the function of the adrenal cortex, does not cause delays Na + in the body and the appearance of edema. Increases glycogenesis, activate catabolic processes. Onset of action – within 12 hours, reaches a maximum at 4-7 days of therapy.
Indications Triamcinolone Acetonide:
Seasonal and perennial allergic rhinitis (prevention and treatment).
Contraindications Triamcinolone Acetonide:
Hypersensitivity, children’s age (6 years), pregnancy, laktatsii.C caution. Tuberculosis, acute fungal, bacterial and viral infections, herpetic eye disease.
Triamcinolone Acetonide Side effects:
Headache, sneezing, coughing, dryness of nasal mucosa, irritation of the nose, epistaxis, pharyngitis, rhinitis, fungal infection of the nose and throat caused by Candida albicans. In children aged 6-12 years – sinusitis, otitis media, rvota.Peredozirovka. Symptoms: possible suppression of the hypothalamic-pituitary-adrenal system and the appearance of symptoms hypercortisolism.
Dosage and administration Triamcinolone Acetonide:
One inhalation dose contains 55 mg triamcinolone. Intranasally, for adults and children older than 12 years: 220 mg / day (2 inhalation dose in each nostril) once, if necessary, dosage may be increased to the maximum, is 440 mg / day (used just once, or divided into 2 – 4 admission). Children aged 6-12 years: 110 mcg / d (1 inhalation dose in each nostril) once. The maximum daily dose – 220 micrograms. After achieving the therapeutic effect in some patients may reduce the daily dose to the minimum maintenance – 110 mg / day dose reduction is carried out gradually, reducing it to 55 mg / day (1 inhalation dose) every 4-7 days.
Special instructions Triamcinolone Acetonide:
Intranasal application for patients with ulcers of the nasal septum, nasal trauma or after surgery in the nose, may slow the healing of wounds. In the case of candidiasis of the mucous membranes of the nose or throat drug should be discontinued and appoint the appropriate therapy.
